with increased competition and discounting, there is an opportunity to significantly reduce costs. I think it might be worthwhile to broaden your search to determine the best resin for your unique circumstances.

Top Commercial Protein A Resins

Cytiva (formerly GE Healthcare)
MabSelect SuRe - Industry standard with high binding capacity (~40 mg IgG/mL) and alkali stability for effective cleaning
MabSelect PrismA - Enhanced productivity with very high binding capacity (~60-80 mg IgG/mL) and improved flow properties
MabSelect VL - Designed for viral clearance with validated low-pH elution

Merck Millipore
Eshmuno A - High binding capacity and good alkali tolerance
ProSep Ultra Plus - Offers high dynamic binding capacity and mechanical stability

Tosoh Bioscience
Toyopearl AF-rProtein A series - Recombinant Protein A ligands with high capacity and stability

Repligen
OPUS - Highly cross-linked agarose base with good binding capacity and flow characteristics

Purolite
DurA Cycle A50 – Flexible cleaning-in-place protocols
Praesto Jetted A50 HipH – High pH elution for pH-sensitive molecules

Key Selection Criteria
When choosing a Protein A resin, consider:
Dynamic binding capacity - Higher capacity allows smaller columns and increased productivity
Alkali stability - Critical for cleaning-in-place (CIP) protocols and resin lifetime
Ligand leaching - Lower leaching reduces downstream contamination
Pressure-flow properties - Important for process scalability
Cost - Protein A resins are expensive, so lifetime and capacity affect economics

MabSelect PrismA and MabSelect SuRe are particularly dominant in industrial monoclonal antibody (mAb) production due to their proven track record and robust performance.